NAD+ for Anti-Aging: The Science

Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme present in every living cell and is essential for hundreds of metabolic processes. It plays a central role in energy production, DNA repair, gene expression, and cellular defense mechanisms. At Rani Beauty Clinic in Renton, WA, Dr. Alexander Landfield offers NAD+ therapy as part of a science-backed approach to cellular health and longevity.

NAD+ levels decline significantly with age. Research suggests that by age 50, most people have roughly half the NAD+ levels they had at age 20. This decline is associated with many hallmarks of aging including mitochondrial dysfunction, impaired DNA repair, increased inflammation, and decreased cellular energy production. The connection between NAD+ depletion and aging has made NAD+ restoration one of the most actively researched areas in longevity science.

NAD+ supplementation can be delivered through several routes. Intravenous NAD+ infusions provide the highest bioavailability, delivering the coenzyme directly into the bloodstream and bypassing digestive metabolism. Subcutaneous injections offer a convenient alternative with good absorption. Oral precursors like nicotinamide riboside and nicotinamide mononucleotide are also available, though their bioavailability is lower than injectable routes. At Rani Beauty Clinic, we offer both IV infusions and injectable NAD+ therapy depending on patient preference and goals.

Patients who undergo NAD+ therapy commonly report increased mental clarity, improved energy levels, better exercise recovery, and enhanced overall sense of vitality. While the subjective benefits are widely reported, it is important to note that the anti-aging benefits of NAD+ supplementation in humans are still being studied in long-term clinical trials. Dr. Landfield provides an honest assessment of what the current evidence supports and designs NAD+ protocols that align with each patient's health goals and expectations.