Safety Information
NAD+ Injections Side Effects
Reviewed by Dr. Alexander Landfield, Board-Certified Neurologist
NAD+ (nicotinamide adenine dinucleotide) injections deliver this essential coenzyme directly into the muscle for cellular energy support, cognitive function, and overall wellness. Side effects are generally mild and well-tolerated. At Rani Beauty Clinic, all NAD+ injections are administered as intramuscular (IM) injections under the supervision of Dr. Alexander Landfield, Board-Certified Neurologist.
Common Side Effects
Injection site soreness or tenderness
mildDuration: 1–3 days
Management: Apply a warm compress to the injection site to promote absorption and reduce discomfort. Gentle movement of the injected muscle (e.g., walking if injected in the thigh) can help alleviate soreness.
Mild redness or bruising at the injection site
mildDuration: 1–5 days
Management: Apply arnica gel if bruising occurs. Rotate injection sites between sessions. Bruising is more common in patients taking blood-thinning medications or supplements.
Temporary warmth or flushing
mildDuration: 15–60 minutes
Management: A brief flushing sensation is a normal physiological response to NAD+ and typically resolves within an hour. Stay hydrated and rest if needed.
Mild nausea
mildDuration: 30 minutes to 2 hours
Management: Eat a light meal before your appointment. Stay hydrated. Nausea is generally mild and brief. If it persists, your provider may adjust the dosage or injection speed for future sessions.
Rare Side Effects
These are uncommon but patients should be aware of them.
- Headache following the injection — typically resolves with hydration and rest
- Fatigue or lightheadedness in the hours following treatment
- Allergic reaction to NAD+ or injection components (extremely rare)
- Muscle cramping near the injection site
When to Contact Your Provider
Call Rani Beauty Clinic at (425) 539-4440 if you experience:
- Signs of allergic reaction: hives, swelling, difficulty breathing, or throat tightness
- Severe pain, increasing redness, or warmth at the injection site (possible infection)
- Persistent nausea or vomiting lasting more than 4 hours
- Chest tightness, palpitations, or shortness of breath after the injection
- Any severe or unexpected reaction following the treatment
How to Minimize Side Effects
- 1Eat a light meal 1–2 hours before your appointment to reduce the likelihood of nausea
- 2Stay well-hydrated before and after the injection
- 3Inform your provider of any allergies, medications, or medical conditions
- 4Rotate injection sites between sessions to minimize soreness and tissue irritation
- 5Avoid strenuous exercise involving the injected muscle group for 24 hours
- 6Start with a lower dose if receiving NAD+ for the first time, and increase gradually based on tolerance
Frequently Asked Questions
Are NAD+ injections painful?
NAD+ IM injections involve a brief needle insertion into the muscle (typically the deltoid or gluteal muscle), which most patients describe as a quick pinch followed by mild pressure. The injection itself takes only a few seconds. Some patients experience temporary soreness at the injection site for 1–3 days, similar to the feeling after a vaccine. At Rani Beauty Clinic, experienced clinicians use proper technique to minimize discomfort.
How often should you get NAD+ injections?
NAD+ injection frequency depends on individual goals and response. Common protocols include weekly injections for an initial loading phase (4–6 weeks), followed by maintenance injections every 2–4 weeks. Some patients benefit from monthly maintenance sessions. Your provider at Rani Beauty Clinic will recommend a personalized schedule based on your wellness goals, lifestyle, and response to treatment.
Can NAD+ injections interact with medications?
NAD+ is a naturally occurring coenzyme in the body, and significant drug interactions are not commonly reported. However, patients should always disclose all current medications and supplements to their provider before beginning NAD+ therapy. Patients taking blood thinners may have an increased risk of injection site bruising. Rani Beauty Clinic conducts a thorough health assessment before initiating any wellness injection program.
What is the difference between NAD+ injections and NAD+ IV therapy?
NAD+ IM injections deliver the coenzyme directly into the muscle, where it is absorbed gradually over several hours. The procedure takes only a few minutes and is performed as a quick office visit. IV therapy delivers NAD+ directly into the bloodstream over 1–4 hours, which may cause more intense flushing and nausea due to the rapid delivery. Rani Beauty Clinic offers IM injections as a convenient, well-tolerated alternative to IV administration.
Who should not get NAD+ injections?
NAD+ injections may not be appropriate for patients who are pregnant or breastfeeding, have active infections or fever, or have known allergies to NAD+ or injection components. Patients with cancer, liver disease, or kidney disease should consult their primary care physician before starting NAD+ therapy. A comprehensive health screening is conducted at Rani Beauty Clinic before any wellness injection protocol is initiated.
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Questions About NAD+ Injections?
Our physician-supervised team is here to address all your concerns. Schedule a consultation to discuss your treatment safely.