Dr. Alexander Landfield
Board-Certified Neurologist & Medical Director
<p>Migraines affect over 39 million Americans and are one of the leading causes of disability worldwide. As a neurologist, Dr. Landfield at Rani Beauty Clinic in Renton, WA brings specialized expertise to understanding the complex neurobiology of migraines and the wellness strategies that can reduce their frequency and severity.</p>
<h2>Understanding Migraine Biology</h2>
<p>Migraines are not simply bad headaches. They are complex neurological events involving cortical spreading depression, a wave of neuronal excitation followed by suppression that spreads across the brain. This triggers activation of the trigeminovascular system, releasing inflammatory neuropeptides including CGRP that dilate blood vessels and produce the characteristic throbbing pain.</p>
<p>The threshold for triggering this cascade varies among individuals and fluctuates based on multiple factors including sleep quality, hormonal status, hydration, stress levels, and nutritional status. Wellness optimization aims to raise this threshold so that triggers are less likely to initiate an attack.</p>
<h2>Nutritional Migraine Management</h2>
<h3>Magnesium</h3> <p>Magnesium deficiency is found in up to 50 percent of migraine patients. Magnesium stabilizes neuronal excitability and blocks NMDA receptors involved in cortical spreading depression. Supplementation with 400 to 600 milligrams of magnesium glycinate or oxide daily has demonstrated meaningful reduction in migraine frequency in clinical trials.</p>
<h3>Riboflavin (Vitamin B2)</h3> <p>At doses of 400 milligrams daily, riboflavin has shown a 50 percent reduction in migraine frequency in placebo-controlled studies. It supports mitochondrial energy production in neurons, addressing the energy deficit that may contribute to migraine susceptibility.</p>
<h3>CoQ10</h3> <p>Coenzyme Q10 at 100 to 300 milligrams daily supports mitochondrial function and has shown benefit for migraine prevention in multiple studies. The mitochondrial theory of migraine suggests that impaired neuronal energy production lowers the threshold for attacks.</p>
<h3>Dietary Triggers</h3> <ul> <li>Common triggers: aged cheese, processed meats, alcohol especially red wine, artificial sweeteners, MSG</li> <li>Caffeine: both excess and withdrawal can trigger migraines, consistency matters more than elimination</li> <li>Dehydration: even mild dehydration can lower migraine threshold</li> <li>Irregular meals: blood sugar drops from skipped meals trigger attacks in many patients</li> <li>Food sensitivities: individual triggers that may require elimination diet to identify</li> </ul>
<h2>Lifestyle Factors in Migraine Prevention</h2>
<h3>Sleep Regularity</h3> <p>Both insufficient and excessive sleep trigger migraines. Maintaining consistent sleep and wake times, even on weekends, is among the most effective lifestyle interventions for migraine prevention. This regularity supports the circadian rhythm regulation that influences migraine susceptibility.</p>
<h3>Stress Management</h3> <p>Stress is the most commonly reported migraine trigger. Interestingly, migraines often occur during the let-down period after stress rather than during the stressful event itself. Consistent stress management practices, rather than alternating between high stress and relaxation, help prevent the cortisol fluctuations associated with attacks.</p>
<h3>Regular Exercise</h3> <p>Moderate aerobic exercise three to five times per week has demonstrated migraine-preventive effects comparable to some medications. Exercise promotes endorphin release, improves sleep, reduces stress, and enhances blood flow regulation. Avoid vigorous exercise during or immediately after a migraine, and stay well-hydrated during workouts.</p>
<h2>NAD+ and Migraine Support</h2>
<p>The mitochondrial theory of migraine has gained substantial traction in neurology. NAD+ therapy supports the mitochondrial energy production that neurons require to maintain their normal excitability threshold. By improving neuronal energy availability, NAD+ therapy may help raise the threshold above which the migraine cascade is triggered.</p>
<p>While NAD+ is not a specific migraine treatment, supporting cellular energy production in the brain aligns with the biological understanding of migraine as an energy-related neurological event. Patients receiving NAD+ therapy at Rani Beauty Clinic have reported improvements in migraine frequency and severity, though individual results vary.</p>
<p>At Rani Beauty Clinic in Renton, WA, Dr. Landfield's neurology expertise informs our approach to migraine support. Schedule a consultation to discuss how wellness optimization can complement your migraine management plan.</p>






